Literature summary for 3.4.22.B5 extracted from

Gomes, C.B.; -Silva, F.S.; Charret, K.D.; Pereira, B.A.; Finkelstein, L.C.; Santos-de-Souza, R.; de Castro Cortes, L.M.; Pereira, M.C.; Rodrigues de Oliveira, F.O.; Alves, C.R.
Increasing in cysteine proteinase B expression and enzymatic activity during invitro differentiation of Leishmania (Viannia) braziliensis First evidence of modulation during morphological transition (2017), Biochimie, 133, 28-36 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	not inhibitory: Z-Phe-Phe-fluoromethyl ketone and trans-epoxysuccinyl-L-leucylamido(4-guanidino)butane; not inhibitory: Z-Phe-Phe-fluoromethyl ketone and trans-epoxysuccinyl-L-leucylamido(4-guanidino)butane; not inhibitory: Z-Phe-Phe-fluoromethyl ketone and trans-epoxysuccinyl-L-leucylamido(4-guanidino)butane	Leishmania braziliensis

Organism

Organism	UniProt	Comment	Textmining
Leishmania braziliensis	A4H5E4	gene name LBRM_08_0810	-
Leishmania braziliensis	A4H5E5	gene name LBRM_08_0820	-
Leishmania braziliensis	A4H5E6	gene name LBRM_08_0830	-
Leishmania braziliensis R619	A4H5E4	gene name LBRM_08_0810	-
Leishmania braziliensis R619	A4H5E5	gene name LBRM_08_0820	-
Leishmania braziliensis R619	A4H5E6	gene name LBRM_08_0830	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
promastigote	expression of Cbp gene tends to decrease during acid pH shock and increases when the temperature rises	Leishmania braziliensis	-

Synonyms

Synonyms	Comment	Organism
LBRM_08_0810	-	Leishmania braziliensis
LBRM_08_0820	-	Leishmania braziliensis
LBRM_08_0830	-	Leishmania braziliensis

General Information

General Information	Comment	Organism
physiological function	The proteolytic activity of Cbp proteins exhibits a gradual increase during the parasite's differentiation with low levels in samples of logarithmic promastigotes phase (3.2 mmol per min and mg protein) to a peak of activity after 72 h of incubation at 32°C (4.2 mmol per min and mg protein) followed by a subsequent decrease of 68 % of peak activity levels after 96 h of incubation at 32°C (2.8 mmol per min and mg protein)	Leishmania braziliensis

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Release 2023.1 (January 2023)